ETIOLOGY



Most of the conditions that may lead to cirrhosis are rarely encountered. Alcohol is by far the commonest cause of cirrhosis in the Western world, while hepatitis B is a major cause in the Third World. Cryptogenic cirrhosis is a di­agnosis of exclusion, but many cases are likely to be an end result of chronic non-A, non-B infec­tion. Causes of hepatic fibrosis alone (e.g., schis­tosomiasis, which leads to fibrosis of portal ven­ous radicles and portal hypertension) are not classified as causes of cirrhosis, because the he­patic lobular pattern is well preserved and he­patocellular dysfunction (e.g., disordered protein synthesis) is usually lacking.





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