Liver Failure



The derangement of hepatocellular function that occurs in cirrhosis manifests as impaired he­patic protein synthesis (hypoalbuminemia, im­paired synthesis of coagulation factors) and fail­ure of normal hepatic detoxification processes. The latter accounts for the development of signs such as spider angiomata and contributes to the development of hepatic encephalopathy, as well as to poorly understood hemodynamic and hormonal disorders that foster the development of as­cites and the hepatorenal syndrome.





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