Pathogenic Mechanisms
The great majority of tubulointerstitial disorders occur as a result of one of three general mechanisms: heredity, toxic injury, or a change in tubule regulation by drugs or hormones. Polycystic kidney disease, familial nephrogenic diabetes insipidus, and Fanconi’s syndrome are disorders of hereditary origin. The specific genetic defects are unknown. Analgesic nephropathy, lead nephropathy, and some types of renal tubular acidosis are representative of toxic injuries. Pituitary diabetes insipidus (ADH deficiency), adrenal salt wasting (deficient mineralocorticoid), and diuretic administration are examples of the last category .
- Elimination of Waste Products of Metabolism and Drugs
- SPECIFIC MANIFESTATIONS OF RENAL DISEASE
- Hematopoietic System
- Restrictive Cardiomyopathy
- Endocrine Systems
- CIRCULATORY PHYSIOLOGY
- THE SLEEP APNEA SYNDROME
- Liver Failure
- Membranoproliferative Glomerulonephritis (MPGN)
- Comprehensive Health-care Program for Children in Foster Care
- DRUG-ASSOCIATED RENAL INJURY
- Other Glomerulonephritides
- CARCINOMA OF THE PANCREAS - Diagnosis
- Women’s Health Program
- OXYGEN
- PERIPHERAL ANEURYSMS AMD FISTULAE
- ACID-PEPTIC DISEASE
- OBLITERATIVE OR OBSTRUCTIVE PULMONARY HYPERTENSION
- HEART DISEASE AND PREGNANCY
- MYOCARDIAL METABOLISM
- Alberto N. v. Hawkins
- Plain Radiographs and Barium Contrast Studies
- Pathogenic Mechanisms - Mechanism of Injury
- GROSS ANATOMY
- OBSTRUCTIVE LUNG DISEASE
- DIFFUSE LUNG DISEASE OF UNKNOWN ETIOLOGY
- CARDIAC DEVELOPMENT
- INFECTIVE ENDOCARDITIS
- Pulmonary Hemorrhagic Disorders
- NONPULMONARY FACTORS
- Phosphate Balance
- CLINICAL TESTS OF DIGESTION AND ABSORPTION
- APPROACH TO THE PATIENT WJTH SUSPECTED MALDIGESTION AND/OR MALABSORPTION
- MICROSCOPIC ANATOMY
- Uremic Osteodystrophy